SUMO modification and its regulation of signaling pathways

Abstract

SUMO modification is a kind of post-translational modification of proteins, which plays an important role in regulating protein stability, protein-protein interaction and subcellular localization. SUMO modification of protein is the main mechanism for the formation of diabetes, tumors and other diseases.It has become the key target for treatment. In this article, we have reviewed the latest advance in the relationship between protein SUMO modification and these pathways which are nuclear factor-κB (NF-κB) signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway and transforming growth factor-β (TGF-β).

Keywords

• sumo modification|nf-κb|mapk|tgf-β