Nature Communications (Sep 2020)
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
- Yongyao Fu,
- Jocelyn Wang,
- Gayathri Panangipalli,
- Benjamin J. Ulrich,
- Byunghee Koh,
- Chengxian Xu,
- Rakshin Kharwadkar,
- Xiaona Chu,
- Yue Wang,
- Hongyu Gao,
- Wenting Wu,
- Jie Sun,
- Robert S. Tepper,
- Baohua Zhou,
- Sarath Chandra Janga,
- Kai Yang,
- Mark H. Kaplan
Affiliations
- Yongyao Fu
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Jocelyn Wang
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Gayathri Panangipalli
- Department of Biohealth Informatics, School of Informatics and Computing, Indiana University-Purdue University
- Benjamin J. Ulrich
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Byunghee Koh
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Chengxian Xu
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Rakshin Kharwadkar
- Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
- Xiaona Chu
- Department of Medical and Molecular Genetics, Indiana University School of Medicine
- Yue Wang
- Department of Medical and Molecular Genetics, Indiana University School of Medicine
- Hongyu Gao
- Department of Medical and Molecular Genetics, Indiana University School of Medicine
- Wenting Wu
- Department of Medical and Molecular Genetics, Indiana University School of Medicine
- Jie Sun
- Department of Medicine, Mayo Clinic
- Robert S. Tepper
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Baohua Zhou
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Sarath Chandra Janga
- Department of Biohealth Informatics, School of Informatics and Computing, Indiana University-Purdue University
- Kai Yang
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Mark H. Kaplan
- Department of Microbiology and Immunology, Indiana University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-18648-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.
