Nature Communications (Mar 2022)
Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity
- A. C. Katz-Summercorn,
- S. Jammula,
- A. Frangou,
- I. Peneva,
- M. O’Donovan,
- M. Tripathi,
- S. Malhotra,
- M. di Pietro,
- S. Abbas,
- G. Devonshire,
- W. Januszewicz,
- A. Blasko,
- K. Nowicki-Osuch,
- S. MacRae,
- A. Northrop,
- A. M. Redmond,
- D. C. Wedge,
- R. C. Fitzgerald
Affiliations
- A. C. Katz-Summercorn
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- S. Jammula
- Cancer Research UK Cambridge Institute, University of Cambridge
- A. Frangou
- Wellcome Centre for Human Genetics, University of Oxford
- I. Peneva
- Wellcome Centre for Human Genetics, University of Oxford
- M. O’Donovan
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- M. Tripathi
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- S. Malhotra
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- M. di Pietro
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- S. Abbas
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- G. Devonshire
- Cancer Research UK Cambridge Institute, University of Cambridge
- W. Januszewicz
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- A. Blasko
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- K. Nowicki-Osuch
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- S. MacRae
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- A. Northrop
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- A. M. Redmond
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- D. C. Wedge
- Manchester Cancer Research Centre, University of Manchester
- R. C. Fitzgerald
- Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-022-28237-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The alterations associated with progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma are not fully characterised. Here, the authors perform a multi-omics analysis of a longitudinally-sampled BE patient cohort, identifying the impact of structural variants, including mobile elements, and the timing of molecular events during progression.
