Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review
Jia Zeng,
Ying Qian,
Jizhuo Yang,
Xinqiang Chen,
Chuanwen Fu,
Zhuohang Che,
Yuemei Feng,
Jianzhong Yin
Affiliations
Jia Zeng
School of Public Health, Kunming Medical University, Kunming, 650500, China
Ying Qian
School of Public Health, Kunming Medical University, Kunming, 650500, China
Jizhuo Yang
School of Public Health, Kunming Medical University, Kunming, 650500, China
Xinqiang Chen
School of Public Health, Kunming Medical University, Kunming, 650500, China
Chuanwen Fu
School of Public Health, Kunming Medical University, Kunming, 650500, China
Zhuohang Che
School of Public Health, Kunming Medical University, Kunming, 650500, China
Yuemei Feng
School of Public Health, Kunming Medical University, Kunming, 650500, China; Corresponding author.
Jianzhong Yin
School of Public Health, Kunming Medical University, Kunming, 650500, China; Baoshan College of Traditional Chinese Medicine, Baoshan, 678000, China; Yunnan Provincial Key Laboratary of Public Health and Biosafety, Kunming, 650500, China; Corresponding author. School of Public Health, Kunming Medical University, Kunming, 650500, China.
Currently, osteoporosis-related fractures become the most cutting-edge problem of diabetes-related complications. Rational diet is not only the basis of glycemic management in type 2 diabetes patients, but also the direction of diabetic bone health.This review highlights the importance of micronutrient supplementation (including calcium, magnesium, zinc, vitamin D, vitamin K, and vitamin C) for patients with T2DM, as well as describing the constructive intermediary role of gut flora between T2DM and bone through nutrients predominantly high in dietary fiber. In addition, it is recommended to combine the Mediterranean dietary pattern with other diversified management approaches to prevent OP. Therefore, this provides a theoretical basis for the potential role of islet β-cells in promoting bone health.
