The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy
Martino Deidda,
Antonio Noto,
Daniele Pasqualucci,
Claudia Fattuoni,
Luigi Barberini,
Cristina Piras,
Pier Paolo Bassareo,
Maurizio Porcu,
Giuseppe Mercuro,
Christian Cadeddu Dessalvi
Affiliations
Martino Deidda
Department of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy
Antonio Noto
Department of Biomedical Sciences, University of Cagliari, 09124 Monserrato, Italy
Daniele Pasqualucci
Cardiothoracic Unit, Azienda Ospedaliera Brotzu, 09134 Cagliari, Italy
Claudia Fattuoni
Department of Chemical and Geological Sciences, University of Cagliari, 09124 Monserrato, Italy
Luigi Barberini
Department of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy
Cristina Piras
Department of Biomedical Sciences, University of Cagliari, 09124 Monserrato, Italy
Pier Paolo Bassareo
School of Medicine, Mater Misericordiae University Hospital and Our Lady’s Children’s Hospital Crumlin, University College of Dublin, D07 R2WY Dublin, Ireland
Maurizio Porcu
Cardiothoracic Unit, Azienda Ospedaliera Brotzu, 09134 Cagliari, Italy
Giuseppe Mercuro
Department of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy
Christian Cadeddu Dessalvi
Department of Medical Sciences and Public Health, University of Cagliari, 09124 Monserrato, Italy
The purpose of this study was to assess whether metabolomics, associated with echocardiography, was able to highlight pathophysiological differences between obstructive (OHCM) or non-obstructive (NOHCM) hypertrophic cardiomyopathy. Thirty-one HCM patients underwent standard and advanced echocardiography; a plasma sample was collected for metabolomic analysis. Results. Patients with OHCM compared with subjects with NOHCM had higher values of 2DLVEF (66.5 ± 3.3% vs. 60.6 ± 1.8%, p p p p = 0.014). The most discriminating metabolites resulted as follows: in the NOHCM Group, there were higher levels of threitol, aminomalonic acid, and sucrose, while the OHCM Group presented higher levels of amino acids, in particular those branched chains, of intermediates of glycolysis (lactate) and the Krebs cycle (fumarate, succinate, citrate), of fatty acids (arachidonic acid, palmitoleic acid), of ketone bodies (2-OH-butyrate). Our data point out a different systolic function related to a specific metabolic activity in the two HCM phenotypic forms, with specific metabolites associated with better contractility in OHCM.
