International Journal of Molecular Sciences (Apr 2023)

Isopropoxy Benzene Guanidine Ameliorates <i>Streptococcus suis</i> Infection In Vivo and In Vitro

  • Ning Han,
  • Jie Li,
  • Feifei Zhao,
  • Yangyang Li,
  • Jun Wang,
  • Xiaolan Dai,
  • Dongping Zeng,
  • Wenguang Xiong,
  • Zhenling Zeng

DOI
https://doi.org/10.3390/ijms24087354
Journal volume & issue
Vol. 24, no. 8
p. 7354

Abstract

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Streptococcus suis, an encapsulated zoonotic pathogen, has been reported to cause a variety of infectious diseases, such as meningitis and streptococcal-toxic-shock-like syndrome. Increasing antimicrobial resistance has triggered the need for new treatments. In the present study, we found that isopropoxy benzene guanidine (IBG) significantly attenuated the effects caused by S. suis infection, in vivo and in vitro, by killing S. suis and reducing S. suis pathogenicity. Further studies showed that IBG disrupted the integrity of S. suis cell membranes and increased the permeability of S. suis cell membranes, leading to an imbalance in proton motive force and the accumulation of intracellular ATP. Meanwhile, IBG antagonized the hemolysis activity of suilysin and decreased the expression of Sly gene. In vivo, IBG improved the viability of S. suis SS3-infected mice by reducing tissue bacterial load. In conclusion, IBG is a promising compound for the treatment of S. suis infections, given its antibacterial and anti-hemolysis activity.

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