Nature Communications (Apr 2022)
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia
- Jani Huuhtanen,
- Dipabarna Bhattacharya,
- Tapio Lönnberg,
- Matti Kankainen,
- Cassandra Kerr,
- Jason Theodoropoulos,
- Hanna Rajala,
- Carmelo Gurnari,
- Tiina Kasanen,
- Till Braun,
- Antonella Teramo,
- Renato Zambello,
- Marco Herling,
- Fumihiro Ishida,
- Toru Kawakami,
- Marko Salmi,
- Thomas Loughran,
- Jaroslaw P. Maciejewski,
- Harri Lähdesmäki,
- Tiina Kelkka,
- Satu Mustjoki
Affiliations
- Jani Huuhtanen
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- Dipabarna Bhattacharya
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- Tapio Lönnberg
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Matti Kankainen
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- Cassandra Kerr
- Translational Hematology and Oncology Department, Taussig Cancer Center, Cleveland Clinic
- Jason Theodoropoulos
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- Hanna Rajala
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- Carmelo Gurnari
- Translational Hematology and Oncology Department, Taussig Cancer Center, Cleveland Clinic
- Tiina Kasanen
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- Till Braun
- Department I of Internal Medicine, Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, University of Cologne (UoC)
- Antonella Teramo
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Renato Zambello
- Department of Medicine (DIMED), Hematology and Clinical Immunology Branch, Padova University School of Medicine
- Marco Herling
- Department I of Internal Medicine, Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, University of Cologne (UoC)
- Fumihiro Ishida
- Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine
- Toru Kawakami
- Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine
- Marko Salmi
- InFlames Flagship Center, University of Turku
- Thomas Loughran
- Division of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia
- Jaroslaw P. Maciejewski
- Translational Hematology and Oncology Department, Taussig Cancer Center, Cleveland Clinic
- Harri Lähdesmäki
- Department of Computer Science, Aalto University
- Tiina Kelkka
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- Satu Mustjoki
- Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-29173-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
T cell large granular lymphocytic leukemia (T-LGLL) is a lymphoproliferative disorder involving clonally expanded T cell clones and is not fully understood. Here the authors show that the rest of the immune repertoire is interconnected with the T-LGLL clonotype(s) and is more mature, cytotoxic and clonally restricted than in other cancers and autoimmune disorders.
