Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold
Sayaka Miura,
Rio Yamagishi,
Riku Miyazaki,
Kaori Yasuda,
Yuki Kawano,
Yoshiyuki Yokoyama,
Naoto Sugino,
Takao Kameda,
Satoshi Takei
Affiliations
Sayaka Miura
Department of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan
Rio Yamagishi
Department of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan
Riku Miyazaki
Department of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan
Kaori Yasuda
Department of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan
Yuki Kawano
Toyama Industrial Technology Research and Development Center, Takaoka, Toyama 933-0981, Japan
Yoshiyuki Yokoyama
Toyama Industrial Technology Research and Development Center, Takaoka, Toyama 933-0981, Japan
Naoto Sugino
Futuristic Technology Department, Sanko Gosei, Nanto, Toyama 939-1852, Japan
Takao Kameda
Futuristic Technology Department, Sanko Gosei, Nanto, Toyama 939-1852, Japan
Satoshi Takei
Department of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan
Hydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile solvents in the imprint materials cause transfer failure in the conventional water impermeable molds of quartz and metal. However, the water permeable mold allows the use of 67 wt% dilution water with high solubility to increase the fluidity of the hydrolyzed hyaluronic acid during the patterning of high-resolution fine microneedles for cosmetics and pharmaceuticals. This demonstration sets a new paradigm of functional pure gels for high-resolution nano-patterning applications with various cosmetic and pharmaceutical materials containing dilution water using a water permeable mold.
