A Facile High-Throughput Model of Surface-Independent Staphylococcus aureus Biofilms by Spontaneous Aggregation

mSphere (Apr 2021)

Affiliations

Terrence Cheng: Department of Chemical and Materials Engineering, San José State University, San José, California, USA
Nelson S. Torres: Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA
Ping Chen: Division of Combat Wound Repair, U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
Anand Srinivasan: BioBridge Global, San Antonio, Texas, USA
Sandra Cardona: Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA
Grace C. Lee: College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA
Kai P. Leung: Division of Combat Wound Repair, U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
Jose L. Lopez-Ribot: ORCiD; Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA
Anand K. Ramasubramanian: ORCiD; Department of Chemical and Materials Engineering, San José State University, San José, California, USA

Abstract

The canonical model of biofilm formation begins with the attachment and growth of microbial cells on a surface. While these in vitro