Frontiers in Human Neuroscience (Apr 2021)
Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies
- Vinata Vedam-Mai,
- Karl Deisseroth,
- Karl Deisseroth,
- James Giordano,
- Gabriel Lazaro-Munoz,
- Winston Chiong,
- Nanthia Suthana,
- Nanthia Suthana,
- Nanthia Suthana,
- Nanthia Suthana,
- Jean-Philippe Langevin,
- Jean-Philippe Langevin,
- Jay Gill,
- Wayne Goodman,
- Nicole R. Provenza,
- Casey H. Halpern,
- Rajat S. Shivacharan,
- Tricia N. Cunningham,
- Sameer A. Sheth,
- Nader Pouratian,
- Katherine W. Scangos,
- Helen S. Mayberg,
- Andreas Horn,
- Kara A. Johnson,
- Kara A. Johnson,
- Christopher R. Butson,
- Christopher R. Butson,
- Ro’ee Gilron,
- Coralie de Hemptinne,
- Coralie de Hemptinne,
- Robert Wilt,
- Maria Yaroshinsky,
- Simon Little,
- Philip Starr,
- Greg Worrell,
- Prasad Shirvalkar,
- Prasad Shirvalkar,
- Edward Chang,
- Jens Volkmann,
- Muthuraman Muthuraman,
- Sergiu Groppa,
- Andrea A. Kühn,
- Luming Li,
- Matthew Johnson,
- Kevin J. Otto,
- Robert Raike,
- Steve Goetz,
- Chengyuan Wu,
- Peter Silburn,
- Binith Cheeran,
- Yagna J. Pathak,
- Mahsa Malekmohammadi,
- Aysegul Gunduz,
- Aysegul Gunduz,
- Joshua K. Wong,
- Stephanie Cernera,
- Stephanie Cernera,
- Wei Hu,
- Aparna Wagle Shukla,
- Adolfo Ramirez-Zamora,
- Wissam Deeb,
- Addie Patterson,
- Kelly D. Foote,
- Michael S. Okun
Affiliations
- Vinata Vedam-Mai
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Karl Deisseroth
- Department of Bioengineering, Stanford University, Stanford, CA, United States
- Karl Deisseroth
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States
- James Giordano
- Department of Neurology and Neuroethics Studies Program, Georgetown University Medical Center, Washington, DC, United States
- Gabriel Lazaro-Munoz
- Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States
- Winston Chiong
- Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States
- Nanthia Suthana
- Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States
- Nanthia Suthana
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States
- Nanthia Suthana
- Department of Psychology, University of California, Los Angeles, Los Angeles, CA, United States
- Nanthia Suthana
- 0Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States
- Jean-Philippe Langevin
- Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States
- Jean-Philippe Langevin
- 1Neurosurgery Service, Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United States
- Jay Gill
- Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States
- Wayne Goodman
- 2Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States
- Nicole R. Provenza
- 3School of Engineering, Brown University, Providence, RI, United States
- Casey H. Halpern
- 4Department of Neurosurgery, Stanford University Medical Center, Stanford, CA, United States
- Rajat S. Shivacharan
- 4Department of Neurosurgery, Stanford University Medical Center, Stanford, CA, United States
- Tricia N. Cunningham
- 4Department of Neurosurgery, Stanford University Medical Center, Stanford, CA, United States
- Sameer A. Sheth
- 5Department of Neurological Surgery, Baylor College of Medicine, Houston, TX, United States
- Nader Pouratian
- Department of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States
- Katherine W. Scangos
- 6Department of Psychiatry, University of California, San Francisco, San Francisco, CA, United States
- Helen S. Mayberg
- 7Department of Neurology and Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Andreas Horn
- 8Movement Disorders & Neuromodulation Unit, Department for Neurology, Charité – University Medicine Berlin, Berlin, Germany
- Kara A. Johnson
- 9Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States
- Kara A. Johnson
- 0Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, United States
- Christopher R. Butson
- 9Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States
- Christopher R. Butson
- 0Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, United States
- Ro’ee Gilron
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Coralie de Hemptinne
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Coralie de Hemptinne
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Robert Wilt
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Maria Yaroshinsky
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Simon Little
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Philip Starr
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Greg Worrell
- 2Department of Neurology, Mayo Clinic, Rochester, MN, United States
- Prasad Shirvalkar
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Prasad Shirvalkar
- 3Department of Anesthesiology (Pain Management) and Neurology, University of California, San Francisco, San Francisco, CA, United States
- Edward Chang
- 1Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Jens Volkmann
- 4Neurologischen Klinik Universitätsklinikum Würzburg, Würzburg, Germany
- Muthuraman Muthuraman
- 5Section of Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
- Sergiu Groppa
- 5Section of Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
- Andrea A. Kühn
- 6Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Luming Li
- 7National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, China
- Matthew Johnson
- 8Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States
- Kevin J. Otto
- 9J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States
- Robert Raike
- 0Restorative Therapies Group Implantables, Research and Core Technology, Medtronic, Minneapolis, MN, United States
- Steve Goetz
- 0Restorative Therapies Group Implantables, Research and Core Technology, Medtronic, Minneapolis, MN, United States
- Chengyuan Wu
- 1Department of Neurological Surgery, Thomas Jefferson University Hospitals, Philadelphia, PA, United States
- Peter Silburn
- 2Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
- Binith Cheeran
- 3Neuromodulation Division, Abbott, Plano, TX, United States
- Yagna J. Pathak
- 3Neuromodulation Division, Abbott, Plano, TX, United States
- Mahsa Malekmohammadi
- 4Boston Scientific Neuromodulation, Valencia, CA, United States
- Aysegul Gunduz
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Aysegul Gunduz
- 9J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States
- Joshua K. Wong
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Stephanie Cernera
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Stephanie Cernera
- 9J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States
- Wei Hu
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Aparna Wagle Shukla
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Adolfo Ramirez-Zamora
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Wissam Deeb
- 5Department of Neurology, University of Massachusetts, Worchester, MA, United States
- Addie Patterson
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Kelly D. Foote
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- Michael S. Okun
- Norman Fixel Institute for Neurological Diseases and the Program for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, United States
- DOI
- https://doi.org/10.3389/fnhum.2021.644593
- Journal volume & issue
-
Vol. 15
Abstract
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank.
Keywords
