Autoinflammatory diseases: what’s behind them and what’s new. A review

Abstract

Autoinflammatory diseases are characterized by bouts of systemic or localized inflammation in the absence of an infection. While some autoinflammatory diseases are caused by a single gene mutation, others have been shown to be multifactorial, involving a large array of genes coupled with environmental factors. Previous studies briefly elucidated the molecular mechanisms behind the many autoinflammatory diseases, focusing on the dysregulation of IL-1β or IL-18, NF-κB activation, and IFN secretion. In this review, we precisely highlight the autoinflammatory disease-specific signalosomes, and we aim to provide a scaffold of the link between the various affected pathways.

Keywords

• Autoinflammatory diseases
• molecular dysregulation
• signalosomes