Nature Communications (Mar 2019)

Large-scale network analysis reveals the sequence space architecture of antibody repertoires

  • Enkelejda Miho,
  • Rok Roškar,
  • Victor Greiff,
  • Sai T. Reddy

DOI
https://doi.org/10.1038/s41467-019-09278-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Analysis of large-scale immune repertoire architecture remains a challenge. Here, the authors introduce an approach to construct similarity networks from high-throughput antibody repertoire sequencing data, and show that the networks are redundant, robust and reproducible across individuals.