Synthesis, characterization and antimicrobial activity of novel benzofuran- and thiophene-containing diketoxime derivatives

Abstract

The aim of this study was the preparation of 1,1′-(2,5-thiophenediyl) bis[1-(2-benzofuranyl)methanone] (2), the corresponding diketoxime (3), and the ether and ester derivatives (4a–e) of the diketoxime. These compounds were prepared in good yields. Minimum inhibitory concentrations (MIC) of the synthesized compounds 1–4 were determined against Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli and Staphylococcus aureus. Among the synthesized compounds, 1 and 4e showed good activity against E. coli, S. enterica and S. aureus.

Keywords

• bisbenzofuran
• thiophene
• diketoxime
• antimicrobial activity