The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies

Joshua D. Bernstock; Samantha E. Hoffman; Jason A. Chen; Saksham Gupta; Ari D. Kappel; Timothy R. Smith; E. Antonio Chiocca

doi:10.3390/v13061158

Viruses (Jun 2021)

The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies

Joshua D. Bernstock,
Samantha E. Hoffman,
Jason A. Chen,
Saksham Gupta,
Ari D. Kappel,
Timothy R. Smith,
E. Antonio Chiocca

Affiliations

Joshua D. Bernstock: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Samantha E. Hoffman: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Jason A. Chen: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Saksham Gupta: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Ari D. Kappel: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Timothy R. Smith: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
E. Antonio Chiocca: Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

DOI: https://doi.org/10.3390/v13061158
Journal volume & issue: Vol. 13, no. 6
p. 1158

Abstract

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Despite advances in surgical resection and chemoradiation, high-grade brain tumors continue to be associated with significant morbidity/mortality. Novel therapeutic strategies and approaches are, therefore, desperately needed for patients and their families. Given the success experienced in treating multiple other forms of cancer, immunotherapy and, in particular, immunovirotherapy are at the forefront amongst novel therapeutic strategies that are currently under investigation for incurable brain tumors. Accordingly, herein, we provide a focused mini review of pertinent oncolytic herpes viruses (oHSV) that are being investigated in clinical trials.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

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Abstract

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