Loop diuretics in the treatment of hypertension and edema syndrome

Abstract

The comparison of the pharmacological properties, clinical efficacy of furosemide and torasemide in patients with hypertension and edema. Torasemid similar to furosemide mechanism of diuretic action but has a higher bioavailability (>80%) and a longer half-life (3–4 h). In-non-diuretic doses (2.5–5 mg/day) torasemide used in the treatment of essential hypertension, both as monotherapy and in combination with other antihypertensive drugs. When used in these doses torasemide reduces diastolic blood pressure to below 90 mm Hg in 70–80% of patients. In patients with chronic heart failure torasemide in a dose of from 5 to 20 mg/day is an effective diuretic. The bioavailability of torasemide when administered in patients with CHF decreases only slightly, the diuretic action is smoother, it is less likely to cause the phenomenon of "rebound". Total and cardiovascular mortality in patients treated with torasemide, was lower (2.2% compared with 4.5% in the comparison group; p<0.05). Pharmacokinetic parameters are not changed when torasemide III (GFR 30-59 ml/min) and IV (GFR 15-29 ml/min) CKD stages. In patients with chronic renal failure therapy furosemide torasemide and is accompanied by a comparable increase in natriuresis and blood pressure reduction.

Keywords

• arterial hypertension
• torasemide
• loop diuretic