Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway

Abstract

Main findings of the study Probiotics controls AHR, eosinophil infiltration to the perivascular and BALF, levels of immunoglobulins, IL-17, GTP and also mucus secretion, goblet cell hyperplasia, EPO activity. It could reduce gene expression of TLR4 and CCL11, Probiotics and prebiotics control levels of cytokines (IL-4, 5, 13, 25, and 33), leukotrienes, the gene expression of AKT, NLR3, NF-κB, MyD88, MUC5a, peribronchial inflammation and increase IL-38 gene expression. Prebiotic controls and PI3K gene expression.

Keywords

• Allergy
• Microbe
• Diet
• Immunomodulation
• Asthma