Comparison of Prophylactic Effects between Localized Biomimetic Minocycline and Systematic Amoxicillin on Implants Placed Immediately in Infected Sockets
Won-Woo Lee,
Jin-Won Seo,
Il-Seok Jang,
Young-Joong Kwon,
Won-Jun Joung,
Jong-Hun Jun,
Jiyeong Kim,
Donghee Son,
Seung-Weon Lim,
Seo-Hyoung Yun,
Marco Tallarico,
Chang-Joo Park
Affiliations
Won-Woo Lee
Division of Oral & Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Jin-Won Seo
Division of Oral & Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Il-Seok Jang
Osstem R&D Center, Seoul 07789, Republic of Korea
Young-Joong Kwon
Osstem R&D Center, Seoul 07789, Republic of Korea
Won-Jun Joung
Division of Oral & Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Jong-Hun Jun
Division of Oral & Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Jiyeong Kim
Department of Pre-Medicine, College of Medicine and Biostatistics Lab, Medical Research Collaborating Center (MRCC), Hanyang University, Seoul 04763, Republic of Korea
Donghee Son
Laboratory of Biostatistical Consulting and Research, Medical Research Collaborating Center, Industry-University Cooperation Foundation, Hanyang University, Seoul 04763, Republic of Korea
Seung-Weon Lim
Division of Orthodontics, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Seo-Hyoung Yun
Division of Oral & Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Marco Tallarico
Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07021 Sassari, Italy
Chang-Joo Park
Division of Oral & Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
This study evaluated the prophylactic effect of localized biomimetic minocycline and systemic amoxicillin on immediate implant placement at infected extraction sites. Twelve mongrels with six implants each were randomly assigned to five groups: uninfected negative control (Group N); infected with oral complex bacteria (Group P); infected and treated with amoxicillin one hour before implant placement (Group A); infected and treated with minocycline during implant placement (Group B); and infected and treated with amoxicillin one hour before implant placement and with minocycline during implant placement (Group C). Radiographic bone level, gingival index (GI), probing depth (PD), papillary bleeding index (PBI), and removal torque (RT) were recorded. There was no significant difference between Groups A, B, and C for bone loss. Group A showed the highest RT, the lowest PBI, and significantly lower GI and PD values than Group P. Group B exhibited significantly higher RT value than Group N and significantly smaller PD value than Group P at 6 w postoperatively. Localized minocycline could improve implant success by reducing bone loss and increasing RT and systemic amoxicillin could maintain the stability of the peri-implant soft tissue. However, combined use of these two antibiotics did not augment the prophylactic effect.
