Nature Communications (Aug 2020)
BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
Abstract
In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.