Nature Communications (Aug 2020)

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

  • Fred C. Lam,
  • Yi Wen Kong,
  • Qiuying Huang,
  • Tu-Lan Vu Han,
  • Amanda D. Maffa,
  • Ekkehard M. Kasper,
  • Michael B. Yaffe

DOI
https://doi.org/10.1038/s41467-020-17503-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 20

Abstract

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In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.