Facilitating the transmetalation step with aryl-zincates in nickel-catalyzed enantioselective arylation of secondary benzylic halides

Abstract

Fluoroalkyl groups are widely found in pharmaceutical products. Here, the authors report a highly enantioselective nickel-catalyzed cross coupling method for the construction of fluoromethylated stereogenic centers via a highly reactive zincate species facilitating the transmetalation step in the nickel catalytic cycle.