Clinical and Translational Allergy (Feb 2022)
Environmental and sensitization variations among asthma and/or rhinitis patients between 2008 and 2018 in China
- Wanjun Wang,
- Jianhong Wang,
- Guihua Song,
- Hua Xie,
- Xiaoping Lin,
- Ruonan Chai,
- Rongfei Zhu,
- Yong He,
- Jun Tang,
- Junge Wang,
- Jinghua Yang,
- Lili Zhi,
- Lin Wu,
- Yan Jiang,
- Xiaoqin Zhou,
- Dongming Huang,
- Ning Wang,
- Rui Xu,
- Yuan Gao,
- Zhimin Chen,
- Jinling Liu,
- Xiaoli Han,
- Guolin Tan,
- Jinzhun Wu,
- Deyu Zhao,
- Jianjun Chen,
- Xiwei Zhang,
- Mengrong Li,
- Yuemei Sun,
- Yi Jiang,
- Weitian Zhang,
- Qianhui Qiu,
- Chuanhe Liu,
- Jie Yin,
- Guodong Hao,
- Huabin Li,
- Yongsheng Xu,
- Shaohua Chen,
- Hua Zhang,
- Shi Chen,
- Juan Meng,
- Dan Zeng,
- Wei Tang,
- Chuangli Hao,
- Jing Li,
- Nanshan Zhong,
- for the China Alliance of Research on Respiratory Allergic Disease
Affiliations
- Wanjun Wang
- Department of Allergy and Clinical Immunology National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University Guangzhou China
- Jianhong Wang
- The First People's Hospital of Yibin Yibin Sichuan China
- Guihua Song
- The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou Henan China
- Hua Xie
- General Hospital of Northern Theater Command Shenyang China
- Xiaoping Lin
- General Hospital of Northern Theater Command Shenyang China
- Ruonan Chai
- General Hospital of Northern Theater Command Shenyang China
- Rongfei Zhu
- Tongji Hospital Tongji Medical College Huazhong University of Science & Technology Wuhan China
- Yong He
- The Affiliated Hospital of Medical School Ningbo University Ningbo Zhejiang China
- Jun Tang
- Foshan First People's Hospital Foshan China
- Junge Wang
- Beijing Hospital of Traditional Chinese Medicine Beijing China
- Jinghua Yang
- Guangdong Provincial Hospital of Chinese Medicine Guangzhou China
- Lili Zhi
- The First Affiliated Hospital of Shandong First Medical University Shandong Institute of Respiratory Diseases Taian China
- Lin Wu
- Hangzhou Hospital of Traditional Chinese Hangzhou China
- Yan Jiang
- The Affiliated Hospital of Qingdao University Qingdao China
- Xiaoqin Zhou
- Hubei Province Maternal and Child Health Hospital Wuhan Hubei China
- Dongming Huang
- Boai Hospital of Zhongshan City Zhongshan China
- Ning Wang
- Xi'an Children's Hospital Shaanxi China
- Rui Xu
- The First Affiliated Hospital of Sun‐Yat University Guangzhou China
- Yuan Gao
- The First Affiliated Hospital of Zhengzhou University Zhengzhou China
- Zhimin Chen
- Children's Hospital of Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou China
- Jinling Liu
- Children's Hospital of Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou China
- Xiaoli Han
- Hebei General Hospital Hebei China
- Guolin Tan
- Third Xiangya Hospital of Central South University Changsha China
- Jinzhun Wu
- The Women and Children's Hospital Affiliated to Xiamen University Xiamen China
- Deyu Zhao
- Children's Hospital of Nanjing Medical University Nanjing China
- Jianjun Chen
- Union Hospital of Tongji Medical College Wuhan China
- Xiwei Zhang
- The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China
- Mengrong Li
- The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China
- Yuemei Sun
- Yu Huang Ding Hospital Yantai China
- Yi Jiang
- The First Hospital of Shanxi Medical University Taiyuan China
- Weitian Zhang
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
- Qianhui Qiu
- Zhujiang Hospital of Southern Medical University Guangzhou China
- Chuanhe Liu
- Children's Hospital Capital Institute of Pediatrics Beijing China
- Jie Yin
- Chengdu First People's Hospital Foshan China
- Guodong Hao
- Tangshan Gongren Hospital Hebei China
- Huabin Li
- ENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai China
- Yongsheng Xu
- Children's Hospital of Tianjin University Tianjin China
- Shaohua Chen
- Guangdong Provincial People's Hospital Guangzhou China
- Hua Zhang
- The First Affiliated Hospital of Xinjiang Medical University Ürümqi China
- Shi Chen
- Hainan Provincial People's Hospital Haikou China
- Juan Meng
- West China Hospital of Sichuan University Chengdu China
- Dan Zeng
- Chongqing General Hospital University of Chinese Academy of Sciences Beijing China
- Wei Tang
- Ruijin Hospital of Shanghai Jiaotong University Shanghai China
- Chuangli Hao
- Children's Hospital of Soochow University Suzhou China
- Jing Li
- Department of Allergy and Clinical Immunology National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University Guangzhou China
- Nanshan Zhong
- Department of Allergy and Clinical Immunology National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University Guangzhou China
- for the China Alliance of Research on Respiratory Allergic Disease
- DOI
- https://doi.org/10.1002/clt2.12116
- Journal volume & issue
-
Vol. 12,
no. 2
pp. n/a – n/a
Abstract
Abstract Background Little is known about the changes in allergen sensitization in China secondary to the environmental variations over the past decade. We aimed at investigating the variations in sensitization among asthma and/or rhinitis patients in China between 2008 and 2018. Methods This study analyzed cross‐sectional data from national surveys conducted in China in 2008 and 2018. After finishing the questionnaire, participants underwent serum specific IgE measurements. A total of 2322 and 2798 patients were enrolled in 2008 and 2018, respectively. The significance of differences in sensitization rates among four regions of China were assessed. Correlation analysis was used to identify the associations of sensitization with climate change and planting of Artemisia desertorum between the two surveys. Results Compared with 2008, the general sensitization rate to mites significantly increased in 2018, which ranked highest among all tested allergens. Sensitization to pollens, especially Artemisia vulgaris, showed the greatest increase in the north. The annual mean temperature, rainfall and relative humidity in all four regions, and the Artemisia desertorum coverage in the northeastern area, increased significantly in 2018 as compared with 2008. From 2008 to 2018, an increase in Dermatophagoides pteronyssinus sensitization was significantly associated with an increase in relative humidity (r = 0.54, p = 0.037). The increase in A. vulgaris sensitization was significantly associated with the increase in the A. desertorum planting area (r = 0.67, p = 0.006) and with a decrease in rainfall (r = −0.59, p = 0.021). Conclusions House dust mites remain the most important allergen in Chinese individuals with asthma and/or rhinitis. Pollen sensitization dramatically increased in northern China. Increases in sensitization to dust mites and Artemisia were related to the increases in humidity and planting area of A. desertorum.
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