Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism

Abstract

Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. We here review recent evidence that PPAR𝛼 contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.