Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

Maria D. Purice; Sean D. Speese; Mary A. Logan

doi:10.1038/ncomms12871

Nature Communications (Sep 2016)

Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

Maria D. Purice,
Sean D. Speese,
Mary A. Logan

Affiliations

Maria D. Purice: Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health and Science University
Sean D. Speese: Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health and Science University
Mary A. Logan: Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health and Science University

DOI: https://doi.org/10.1038/ncomms12871
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Glial engulfment declines with age, but the mechanism is unclear. Here authors show that in the Drosophilaolfactory system, glial phagocytosis of injury-induced degenerating axons decreases with age due to reduced PI3K/Draper activity, and restoring Draper in aged glia rescues such defects.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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