Synthesis and

Rajesh A. Rane; Mukesh Nandave; Suresh Nayak; Anushri Naik; Dhwani Shah; Wesam S. Alwan; Niteshkumar U. Sahu; Shital S. Naphade; Mahesh B. Palkar; Sivanandhan Karunanidhi; Neeta Thapliyal; Rajshekhar Karpoormath

doi:10.1016/j.arabjc.2014.06.004

Arabian Journal of Chemistry (May 2017)

Synthesis and

Rajesh A. Rane,
Mukesh Nandave,
Suresh Nayak,
Anushri Naik,
Dhwani Shah,
Wesam S. Alwan,
Niteshkumar U. Sahu,
Shital S. Naphade,
Mahesh B. Palkar,
Sivanandhan Karunanidhi,
Neeta Thapliyal,
Rajshekhar Karpoormath

Affiliations

Rajesh A. Rane: Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa
Mukesh Nandave: Department of Pharmacology, SPP School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai 400056, India
Suresh Nayak: Department of Pharmacology, SPP School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai 400056, India
Anushri Naik: Department of Pharmaceutical Chemistry, SPP School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai 400056, India
Dhwani Shah: Department of Pharmaceutical Chemistry, SPP School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai 400056, India
Wesam S. Alwan: Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa
Niteshkumar U. Sahu: Department of Pharmaceutical Chemistry, SPP School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai 400056, India
Shital S. Naphade: Piramal Health Care Ltd, Goregaon, Mumbai, India
Mahesh B. Palkar: Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa
Sivanandhan Karunanidhi: Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa
Neeta Thapliyal: Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa
Rajshekhar Karpoormath: Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa

DOI: https://doi.org/10.1016/j.arabjc.2014.06.004
Journal volume & issue: Vol. 10, no. 4
pp. 458 – 464

Abstract

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Hybrids of bromopyrrole alkaloids with aroyl hydrazone feature were synthesized and evaluated for their anti-inflammatory activity using the carrageenan induced rat paw edema method. All the tested hybrids showed good anti-inflammatory activity with 64.78–86.03% inhibition of edema. Most active hybrids 4b and 4f were further investigated for antihistaminic H1 [4b −8.09 μg/mL (18.5 μM); 4f −9.26 μg/mL (24.05 μM)] and anti-serotonergic 5-HT3 [4b −7.01 μg/mL (16.04 μM); 4f −9.64 μg/mL (25.04 μM)] activities. Molecule 4f with anti-inflammatory, anti-histaminic and anti-serotonergic activities emerges as a potential anti-inflammatory lead form in this study.

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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