Frontiers in Neuroscience (Oct 2022)
Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets
- Tianyuan Zou,
- Tianyuan Zou,
- Tianyuan Zou,
- Bin Ye,
- Bin Ye,
- Bin Ye,
- Kaili Chen,
- Kaili Chen,
- Kaili Chen,
- Andi Zhang,
- Andi Zhang,
- Andi Zhang,
- Dongye Guo,
- Dongye Guo,
- Dongye Guo,
- Yi Pan,
- Yi Pan,
- Yi Pan,
- Rui Ding,
- Rui Ding,
- Rui Ding,
- Haixia Hu,
- Haixia Hu,
- Haixia Hu,
- Xingmei Sun,
- Xingmei Sun,
- Xingmei Sun,
- Mingliang Xiang,
- Mingliang Xiang,
- Mingliang Xiang
Affiliations
- Tianyuan Zou
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Tianyuan Zou
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Tianyuan Zou
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Bin Ye
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Bin Ye
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Bin Ye
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Kaili Chen
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Kaili Chen
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Kaili Chen
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Andi Zhang
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Andi Zhang
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Andi Zhang
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Dongye Guo
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Dongye Guo
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Dongye Guo
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Yi Pan
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yi Pan
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yi Pan
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Rui Ding
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Rui Ding
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Rui Ding
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Haixia Hu
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Haixia Hu
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Haixia Hu
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Xingmei Sun
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Xingmei Sun
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Xingmei Sun
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Mingliang Xiang
- Department of Otolaryngology and Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Mingliang Xiang
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Mingliang Xiang
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- DOI
- https://doi.org/10.3389/fnins.2022.998507
- Journal volume & issue
-
Vol. 16
Abstract
Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as mitochondrial dynamics. As an important approach to regulating mitochondrial function and quantity, the role of mitochondrial dynamics has been demonstrated in the pathogenesis of various disease models, including brain damage, neurodegeneration, and stress. As the vital organ of the peripheral auditory system, the cochlea consumes a significant amount of energy, and the maintenance of mitochondrial homeostasis is essential for the cochlear auditory capacity. OPA1 functions as both a necessary gene regulating mitochondrial fusion and a pathogenic gene responsible for auditory neuropathy, suggesting that an imbalance in mitochondrial dynamics may play a critical role in hearing loss, but relevant studies are few. In this review, we summarize recent evidence regarding the role of mitochondrial dynamics in the pathogenesis of noise-induced hearing loss (NIHL), drug-induced hearing loss, hereditary hearing loss, and age-related hearing loss. The impacts of impaired mitochondrial dynamics on hearing loss are discussed, and the potential of mitochondrial dynamics for the prevention and treatment of hearing loss is considered.
Keywords
