Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Chi Zhang; Ziling Zeng; Dong Cui; Shasha He; Yuyan Jiang; Jingchao Li; Jiaguo Huang; Kanyi Pu

doi:10.1038/s41467-021-23194-w

Nature Communications (May 2021)

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Chi Zhang,
Ziling Zeng,
Dong Cui,
Shasha He,
Yuyan Jiang,
Jingchao Li,
Jiaguo Huang,
Kanyi Pu

Affiliations

Chi Zhang: School of Chemical and Biomedical Engineering, Nanyang Technological University
Ziling Zeng: School of Chemical and Biomedical Engineering, Nanyang Technological University
Dong Cui: School of Chemical and Biomedical Engineering, Nanyang Technological University
Shasha He: School of Chemical and Biomedical Engineering, Nanyang Technological University
Yuyan Jiang: School of Chemical and Biomedical Engineering, Nanyang Technological University
Jingchao Li: School of Chemical and Biomedical Engineering, Nanyang Technological University
Jiaguo Huang: School of Chemical and Biomedical Engineering, Nanyang Technological University
Kanyi Pu: School of Chemical and Biomedical Engineering, Nanyang Technological University

DOI: https://doi.org/10.1038/s41467-021-23194-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Proteolysis targeting chimeras (PROTACs) is an effective alternative to modulate protein homeostasis but can lead to uncontrollable protein degradation and off-target side effects. Here, the authors developed semiconducting polymer nano-PROTACs with phototherapeutic and activatable protein degradation abilities for photo-immunometabolic cancer therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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