Waike lilun yu shijian (Jun 2022)

Diagnosis and treatment of medullary thyroid carcinoma-an update

  • CHEN Chengkun, GUO Bomin, DENG Xianzhao, WU Bo, FAN Youben

DOI
https://doi.org/10.16139/j.1007-9610.2022.03.019
Journal volume & issue
Vol. 27, no. 03
pp. 276 – 280

Abstract

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Medullary thyroid carcinoma (MTC) arising from the parafollicular cell (C cell) of the thyroid gland, is an aggressive neuroendocrine tumor and a special rare thyroid malignancy. Calcitonin and carcinoembryonic antigen are still commonly used markers now, whose elevation can reliably diagnose MTC. The preoperative value and postoperative doubling time of these markers are of great significance for range of lymph node dissection and evaluation of prognosis. It is recommended that total thyroidectomy and central lymph node dissection would be needed and lateral lymph node dissection would be added when necessary. Routine detection of RET gene is recommended. Targeted therapy is considered for non-operable patients or the patients with distant metastasis. The pathological mechanism of MTC still needs to be paid attention.

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