Inactivated COVID-19 vaccination and SARS-CoV-2 infection among Chinese adults in the “living with COVID” era
Hongbiao Chen,
Siyu Chen,
Lei Liu,
Yuan Fang,
Xue Liang,
Dongmei Liang,
Lixian Su,
Weijun Peng,
Xiaofeng Zhou,
Jingwei Luo,
Zixin Wang
Affiliations
Hongbiao Chen
Department Epidemiology and Infectious Disease Control, Longhua District Centre for Disease Control and Prevention, Shenzhen, 518110, China
Siyu Chen
Centre for Health Behaviours Research, JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, 999077, Hong Kong, China
Lei Liu
Department of Disease Control, Longgang District Nanwan Centre for Public Health, Shenzhen, 518100, China
Yuan Fang
Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong, 999077, China
Xue Liang
Centre for Health Behaviours Research, JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, 999077, Hong Kong, China
Dongmei Liang
Department of Environmental and School Health Supervision, Baoan District Centre for Public Health, Shenzhen, 518000, China
Lixian Su
Department of Child Healthcare, Shenzhen Futian District Maternity & Child Healthcare Hospital, Shenzhen, 518045, China
Weijun Peng
Department Epidemiology and Infectious Disease Control, Longhua District Centre for Disease Control and Prevention, Shenzhen, 518110, China
Xiaofeng Zhou
Department Epidemiology and Infectious Disease Control, Longhua District Centre for Disease Control and Prevention, Shenzhen, 518110, China
Jingwei Luo
Department Epidemiology and Infectious Disease Control, Longhua District Centre for Disease Control and Prevention, Shenzhen, 518110, China
Zixin Wang
Centre for Health Behaviours Research, JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, 999077, Hong Kong, China; Corresponding author. Centre for Health Behaviours Research, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Room 508, School of Public Health, Prince of Wales Hospital, Shatin, N.T, Hong Kong, 999077, China.
The objective of this research was to examine the correlation between the status of inactivated COVID-19 vaccination and self-reported confirmed SARS-CoV-2 infection among adults after China entered the ''living with COVID” era. A cross-sectional online survey was conducted among parents or guardians of students attending all 220 kindergartens and 105 primary or secondary schools in Longhua District of Shenzhen, China during March 1 to 9, 2023. The participating schools invited all parents or guardians of their students to complete the online survey. The study focused on a sub-sample of 68,584 participants who were either unvaccinated (n = 2152) or only receiving inactivated COVID-19 vaccination (n = 66,432). Logistic regression was employed for data analysis. Prior to the implementation of the ''living with COVID'' policy, 83.5% of the participants received three doses of inactivated COVID-19 vaccines; 63.0% reported being infected with the SARS-CoV-2 after the policy change. In a multivariate analysis, participants who had received a third dose within the past 6 months were less likely to be infected with SARS-CoV-2, as compared to those who had not completed the primary vaccination series (4–6 months: AOR: 0.84, 95%CI: 0.77, 0.92; ≤3 months: AOR: 0.82, 95%CI: 0.73, 0.92). Despite the high coverage, our results suggested that three doses of inactivated COVID-19 vaccines did not provide adequate protection against SARS-CoV-2 infection among Chinese adults.
