Nature Communications (Nov 2017)

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

  • Shuo Qie,
  • Mrinmoyee Majumder,
  • Katarzyna Mackiewicz,
  • Breege V. Howley,
  • Yuri K. Peterson,
  • Philip H. Howe,
  • Viswanathan Palanisamy,
  • J. Alan Diehl

DOI
https://doi.org/10.1038/s41467-017-01199-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the bypass of senescence and neoplastic progression.