International Journal of General Medicine (Jan 2023)
Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma
Abstract
Hongliang Wu,1– 3 Sihang Zheng,4 Qun He,5 Yan Li3 1Department of Orthopedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People’s Republic of China; 2Department of Orthopedics, Fuzhou Second Hospital, Fuzhou, People’s Republic of China; 3Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China; 4Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China; 5Department of Bioinformatics, School of Life Sciences, China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Yan Li; Qun He, Email [email protected]; [email protected]: Osteosarcoma is the most common primary malignant bone tumor in young adult, which is prone to early metastasis and poor prognosis. The current treatment methods need to be improved. Circular RNA is a covalently blocked circular, non-coding RNA that plays an essential role in the occurrence, development, clinical diagnosis, and treatment of various diseases. Recently, an increasing number of circRNAs have been identified in osteosarcoma. Understanding its role in osteosarcoma is conducive to the early detection, diagnosis, and treatment of osteosarcoma. In this paper, we reviewed the mechanism of action of circular RNA in the occurrence and development of osteosarcoma and its clinical application in recent years.Keywords: osteosarcoma, circular RNA, biomarker, exosome
