Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules
Xingran Kou,
Xinping Zhang,
Ying Cheng,
Miao Yu,
Qingran Meng,
Qinfei Ke
Affiliations
Xingran Kou
Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, China
Xinping Zhang
Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, China
Ying Cheng
Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, China
Miao Yu
Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, China
Qingran Meng
Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, China
Qinfei Ke
Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, China
Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO2), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO2 reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface.
