Targeting the hypoxia pathway to treat pancreatic cancer

Abstract

Lori A Erickson,1 W Edward Highsmith Jr,1 Peiwen Fei,2 Jun Zhang1 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; 2University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, USA Abstract: The correlation between hypoxia and pancreatic cancer has long been discussed. Hao’s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao’s research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion. Keywords: hypoxia, HIF-1, pancreatic cancer