Genetic restriction of humoral immune response

Abstract

The review provides information about immune response initiation against foreign agents. Significance of separate molecules of major histocompatibility complex in antibodies formation after blood transfusion, during pregnancy, after organ transplantation due to incompatibility of the antigenic structures of donor and recipient, mother and child was shown. Detailed description of platelet antigens protein structure significance in immunocompetent cells recognition of them is provided.

Keywords

• immune response restriction
• genes and antigens of major histocompatibility complex HLA (Human Leukocyte Antigens)
• platelet- specific genes of HPA system (Human Platelet Antigens)
• alloimmunization
• transfusiology
• neonatal alloimmune thrombocytopenic pu