Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Kamilla Westarp Zornhagen; Malene M. Clausen; Anders E. Hansen; Ian Law; Fintan J. McEvoy; Svend A. Engelholm; Andreas Kjær; Annemarie T. Kristensen

doi:10.3390/diagnostics5030372

Diagnostics (Sep 2015)

Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Kamilla Westarp Zornhagen,
Malene M. Clausen,
Anders E. Hansen,
Ian Law,
Fintan J. McEvoy,
Svend A. Engelholm,
Andreas Kjær,
Annemarie T. Kristensen

Affiliations

Kamilla Westarp Zornhagen: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, Denmark
Malene M. Clausen: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark
Anders E. Hansen: Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345E, DK-2800 Kgs. Lyngby, Denmark
Ian Law: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark
Fintan J. McEvoy: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, Denmark
Svend A. Engelholm: Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2200 Copenhagen N, Denmark
Andreas Kjær: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark
Annemarie T. Kristensen: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, Denmark

DOI: https://doi.org/10.3390/diagnostics5030372
Journal volume & issue: Vol. 5, no. 3
pp. 372 – 382

Abstract

Read online

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using 18F-FDG, 64Cu-ATSM, and 18F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in 18F-FDG and 18F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

About the journal

Abstract

Keywords