Research in Pharmaceutical Sciences (Jan 2016)

Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities

  • Elham Jafari,
  • Marzieh Rahmani Khajouei,
  • Farshid Hassanzadeh,
  • Gholam Hossein Hakimelahi,
  • Ghadam Ali Khodarahmi

Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.

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