Characteristics of COVID-19 Infection in a Hospitalized Autoimmune Hepatitis Patient
Vanessa Duarte da Costa,
Wilian Jean Wiggers,
Claudia Alexandra Pontes Ivantes,
Rodrigo Jardim Monteiro da Fonseca,
Alberto Martín Rivera Dávila,
Otacilio C. Moreira,
Beatriz Iandra da Silva Ferreira,
Vanessa Salete de Paula,
Lucas Lima da Silva,
Alanna Calheiros Santos,
Livia Melo Villar
Affiliations
Vanessa Duarte da Costa
Brazilian Reference Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Wilian Jean Wiggers
Service of Gastroenterology, Hepatology and Liver Transplantation, Hospital Nossa Senhora das Graças, R. Alcides Munhoz, 433, Mercês, Curitiba 80810-040, Brazil
Claudia Alexandra Pontes Ivantes
Service of Gastroenterology, Hepatology and Liver Transplantation, Hospital Nossa Senhora das Graças, R. Alcides Munhoz, 433, Mercês, Curitiba 80810-040, Brazil
Rodrigo Jardim Monteiro da Fonseca
Computational and Systems Biology Laboratory, Graduate Program in Biodiversity and Health, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Alberto Martín Rivera Dávila
Computational and Systems Biology Laboratory, Graduate Program in Biodiversity and Health, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Otacilio C. Moreira
Molecular Virology Laboratory, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Beatriz Iandra da Silva Ferreira
Molecular Virology Laboratory, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Vanessa Salete de Paula
Molecular Virology Laboratory, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Lucas Lima da Silva
Brazilian Reference Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Alanna Calheiros Santos
Brazilian Reference Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Livia Melo Villar
Brazilian Reference Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a major public health worldwide. Hepatic dysfunction has been seen in patients with COVID-19 and could be related to a viral cytopathic effect, an exacerbated immune reaction, or drug-induced liver damage. Currently, routine modification of immunosuppressive therapy in patients with autoimmune hepatitis (AIH) before and after SARS-CoV-2 infection remains an important topic to be discussed. However, there is little evidence about this thematic to support any recommendation. Here, we described a case report in which the use of an immunosuppressive drug by a patient with diagnosed AIH might have influenced the COVID-19 clinical course with altered laboratory hematological and biochemical parameters during infection.
