Nature Communications (Jun 2022)
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees
- Emanuele Andreano,
- Ida Paciello,
- Silvia Marchese,
- Lorena Donnici,
- Giulio Pierleoni,
- Giulia Piccini,
- Noemi Manganaro,
- Elisa Pantano,
- Valentina Abbiento,
- Piero Pileri,
- Linda Benincasa,
- Ginevra Giglioli,
- Margherita Leonardi,
- Piet Maes,
- Concetta De Santi,
- Claudia Sala,
- Emanuele Montomoli,
- Raffaele De Francesco,
- Rino Rappuoli
Affiliations
- Emanuele Andreano
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Ida Paciello
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Silvia Marchese
- Department of Pharmacological and Biomolecular Sciences DiSFeB, University of Milan
- Lorena Donnici
- INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Giulio Pierleoni
- VisMederi S.r.l
- Giulia Piccini
- VisMederi S.r.l
- Noemi Manganaro
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Elisa Pantano
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Valentina Abbiento
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Piero Pileri
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Linda Benincasa
- VisMederi Research S.r.l.
- Ginevra Giglioli
- VisMederi Research S.r.l.
- Margherita Leonardi
- VisMederi S.r.l
- Piet Maes
- KU Leuven, Rega Institute, Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology
- Concetta De Santi
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Claudia Sala
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- Emanuele Montomoli
- VisMederi S.r.l
- Raffaele De Francesco
- Department of Pharmacological and Biomolecular Sciences DiSFeB, University of Milan
- Rino Rappuoli
- Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences
- DOI
- https://doi.org/10.1038/s41467-022-31115-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
Here, Andreano and Paciello et al. show, at single cell level, the functional and genetic characteristics underlying the Omicron BA.1 and BA.2 cross-protective antibody response in naïve and previously infected COVID-19 vaccinees.
