STUDY OF BIOCHEMICAL ACTIVITY OF EXTRACTS OF SAUSSUREA CONTROVERSA DC. AND FILIPENDULA ULMARIA (L.) MAXIM. IN EXPERIMENTAL OSTEOMYELITIS

Abstract

Aim. The influence of dry extracts of Saussurea controversa DC. and Filipendula ulmaria (L.) Maxim. in experimental osteomyelitis with the use of сefazolin in rats.Materials and methods. After a course of therapy extracts at a dose of 100 mg/kg on the background of antibiotic therapy observed localization of the inflammatory process, whereas animals receiving only Cefazolin becomes diffuse inflammation. In the conditions of complex therapy the level of diene conjugates significantly reduces in the serum and the level of TBA-active products, total lipids and lysophosphatidylcholine reduces in the muscle tissue of the affected area. In the application of extracts of S. controversa returns to normal level of diacylglycerides and phosphatidylcholine, and the application of the extract of F. ulmaria – free cholesterol in comparison with the group of animals treated only with сefazolin.Results. In the application of water-ethanol extract of S. controversa with simultaneous intramuscular сefazolin marked decrease in the activity of acid and alkaline phosphatase that can enhance reparative processes in the bone tissue.

Keywords

• saussurea controversa dc.
• filipendula ulmaria (l.) maxim.
• сухие экстракты
• экспериментальный остеомиелит
• биохимические исследования.