Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Piyushkumar A. Mundra; Nathalie Dhomen; Manuel Rodrigues; Lauge Hjorth Mikkelsen; Nathalie Cassoux; Kelly Brooks; Sara Valpione; Jorge S. Reis-Filho; Steffen Heegaard; Marc-Henri Stern; Sergio Roman-Roman; Richard Marais

doi:10.1038/s41467-020-20432-5

Nature Communications (Jan 2021)

Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Piyushkumar A. Mundra,
Nathalie Dhomen,
Manuel Rodrigues,
Lauge Hjorth Mikkelsen,
Nathalie Cassoux,
Kelly Brooks,
Sara Valpione,
Jorge S. Reis-Filho,
Steffen Heegaard,
Marc-Henri Stern,
Sergio Roman-Roman,
Richard Marais

Affiliations

Piyushkumar A. Mundra: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Nathalie Dhomen: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Manuel Rodrigues: Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer
Lauge Hjorth Mikkelsen: Department of Pathology/Eye Pathology Section, University of Copenhagen
Nathalie Cassoux: Institut Curie, PSL Research University, Department of Ocular Oncology
Kelly Brooks: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Sara Valpione: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
Jorge S. Reis-Filho: Experimental Pathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center
Steffen Heegaard: Department of Pathology/Eye Pathology Section, University of Copenhagen
Marc-Henri Stern: Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer
Sergio Roman-Roman: Institut Curie, PSL Research University, Translational Research Department
Richard Marais: Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester

DOI: https://doi.org/10.1038/s41467-020-20432-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 7

Abstract

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Mucosal melanomas are not thought to be UV radiation (UVR)-driven, yet some present UVR-related mutations. Here the authors show that some mucosal melanomas, especially conjunctival, present mutations characteristic of UVR exposure, yet share structural variants typical of other mucosal melanomas.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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