Disruption of the autism-associated gene SCN2A alters synaptic development and neuronal signaling in patient iPSC-glutamatergic neurons

• Chad O. Brown,
• Chad O. Brown,
• Jarryll A. Uy,
• Jarryll A. Uy,
• Nadeem Murtaza,
• Nadeem Murtaza,
• Elyse Rosa,
• Alexandria Alfonso,
• Biren M. Dave,
• Biren M. Dave,
• Savannah Kilpatrick,
• Savannah Kilpatrick,
• Annie A. Cheng,
• Sean H. White,
• Stephen W. Scherer,
• Stephen W. Scherer,
• Karun K. Singh,
• Karun K. Singh,
• Karun K. Singh

Affiliations

Chad O. Brown

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Chad O. Brown

Krembil Research Institute, University Health Network, Toronto, ON, Canada

Jarryll A. Uy

Krembil Research Institute, University Health Network, Toronto, ON, Canada

Jarryll A. Uy

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

Nadeem Murtaza

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Nadeem Murtaza

Krembil Research Institute, University Health Network, Toronto, ON, Canada

Elyse Rosa

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Alexandria Alfonso

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Biren M. Dave

Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

Biren M. Dave

SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada

Savannah Kilpatrick

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Savannah Kilpatrick

Krembil Research Institute, University Health Network, Toronto, ON, Canada

Annie A. Cheng

Krembil Research Institute, University Health Network, Toronto, ON, Canada

Sean H. White

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Stephen W. Scherer

Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

Stephen W. Scherer

SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada

Karun K. Singh

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada

Karun K. Singh

Krembil Research Institute, University Health Network, Toronto, ON, Canada

Karun K. Singh

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada