Nature Communications (Oct 2017)
A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction
- Paishiun N. Hsieh,
- Guangjin Zhou,
- Yiyuan Yuan,
- Rongli Zhang,
- Domenick A. Prosdocimo,
- Panjamaporn Sangwung,
- Anna H. Borton,
- Evgenii Boriushkin,
- Anne Hamik,
- Hisashi Fujioka,
- Ciaran E. Fealy,
- John P. Kirwan,
- Maureen Peters,
- Yuan Lu,
- Xudong Liao,
- Diana Ramírez-Bergeron,
- Zhaoyang Feng,
- Mukesh K. Jain
Affiliations
- Paishiun N. Hsieh
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Guangjin Zhou
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Yiyuan Yuan
- Department of Pharmacology, Case Western Reserve University
- Rongli Zhang
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Domenick A. Prosdocimo
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Panjamaporn Sangwung
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Anna H. Borton
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Evgenii Boriushkin
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Anne Hamik
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Hisashi Fujioka
- Electron Microscopy Facility
- Ciaran E. Fealy
- Department of Biomedical Sciences, Kent State University
- John P. Kirwan
- Department of Pathobiology, Lerner Research Institute
- Maureen Peters
- Department of Biology, Oberlin College
- Yuan Lu
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Xudong Liao
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Diana Ramírez-Bergeron
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- Zhaoyang Feng
- Department of Pharmacology, Case Western Reserve University
- Mukesh K. Jain
- Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University
- DOI
- https://doi.org/10.1038/s41467-017-00899-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
KLF family transcription factors (KLFs) regulate many cellular processes, including proliferation, survival and stress responses. Here, the authors position KLFs as important regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of age-associated vascular phenotypes in mammals.
