Journal of Inflammation Research (Mar 2023)

MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury

  • Yu B,
  • Zhang Y,
  • Wang T,
  • Guo J,
  • Kong C,
  • Chen Z,
  • Ma X,
  • Qiu T

Journal volume & issue
Vol. Volume 16
pp. 1405 – 1418

Abstract

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Bo Yu,* Yalong Zhang,* Tianyu Wang, Jiayu Guo, Chenyang Kong, Zhongbao Chen, Xiaoxiong Ma, Tao Qiu Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tao Qiu, Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of China, Tel +86-13995632367, Email [email protected]: The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation. It has been widely studied in the occurrence and development of inflammation and tumor. Hepatic ischemia-reperfusion injury (HIRI) is a common pathophysiological phenomenon that occurs in surgical procedures such as lobectomy and liver transplantation, which is characterized by severe inflammatory reaction after ischemia and reperfusion. In this review, we mainly discuss the role of p38, ERK1/2, JNK in MAPK family and TAK1 and ASK1 in MAPKKK family in HIRI, and try to find an effective treatment for HIRI.Keywords: ischemia/reperfusion injury, mitogen-activated protein kinases, liver

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