Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters

Yu-Ping Lin; Daniel Bakowski; Gary R. Mirams; Anant B. Parekh

doi:10.1038/s41467-019-10329-3

Nature Communications (Jun 2019)

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters

Yu-Ping Lin,
Daniel Bakowski,
Gary R. Mirams,
Anant B. Parekh

Affiliations

Yu-Ping Lin: Department of Physiology, Anatomy and Genetics, Oxford University
Daniel Bakowski: Department of Physiology, Anatomy and Genetics, Oxford University
Gary R. Mirams: Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, Nottingham University
Anant B. Parekh: Department of Physiology, Anatomy and Genetics, Oxford University

DOI: https://doi.org/10.1038/s41467-019-10329-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Endoplasmic reticulum Ca2+ sensing STIM proteins and plasma membrane Orai1 channels together regulate Ca2+ influx in eukaryotic cells. Here authors show that two Ca2+-dependent transcription factors, NFAT1 and c-fos, have different requirements for the number of STIM1-Orai1 clusters and on the Ca2+ flux through the clusters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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