Neural Regeneration Research (Jan 2022)

Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study

  • Ya-Fei Wen,
  • Xue-Wen Xiao,
  • Lu Zhou,
  • Ya-Ling Jiang,
  • Yuan Zhu,
  • Li-Na Guo,
  • Xin Wang,
  • Hui Liu,
  • Ya-Fang Zhou,
  • Jun-Ling Wang,
  • Xin-Xin Liao,
  • Lu Shen,
  • Bin Jiao

DOI
https://doi.org/10.4103/1673-5374.321000
Journal volume & issue
Vol. 17, no. 3
pp. 682 – 689

Abstract

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SNCA, GBA, and VPS35 are three common genes associated with Parkinson’s disease. Previous studies have shown that these three genes may be associated with Alzheimer’s disease (AD). However, it is unclear whether these genes increase the risk of AD in Chinese populations. In this study, we used a targeted gene sequencing panel to screen all the exon regions and the nearby sequences of GBA, SNCA, and VPS35 in a cohort including 721 AD patients and 365 healthy controls from China. The results revealed that neither common variants nor rare variants of these three genes were associated with AD in a Chinese population. These findings suggest that the mutations in GBA, SNCA, and VPS35 are not likely to play an important role in the genetic susceptibility to AD in Chinese populations. The study was approved by the Ethics Committee of Xiangya Hospital, Central South University, China on March 9, 2016 (approval No. 201603198).

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