Nature Communications (Aug 2022)
A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice
- Weiping Dai,
- Mengqian Yang,
- Pei Xia,
- Chuan Xiao,
- Shuying Huang,
- Zhan Zhang,
- Xin Cheng,
- Wenchang Li,
- Jian Jin,
- Jingyun Zhang,
- Binghuo Wu,
- Yingying Zhang,
- Pei-hui Wu,
- Yangyang Lin,
- Wen Wu,
- Hu Zhao,
- Yan Zhang,
- Wei-Jye Lin,
- Xiaojing Ye
Affiliations
- Weiping Dai
- Brain Research Center, Sun Yat-sen Memorial Hospital and Zhongshan School of Medicine, Sun Yat-sen University
- Mengqian Yang
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- Pei Xia
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- Chuan Xiao
- Brain Research Center, Sun Yat-sen Memorial Hospital and Zhongshan School of Medicine, Sun Yat-sen University
- Shuying Huang
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- Zhan Zhang
- Brain Research Center, Sun Yat-sen Memorial Hospital and Zhongshan School of Medicine, Sun Yat-sen University
- Xin Cheng
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- Wenchang Li
- Department of Joint Surgery, the First Affiliated Hospital, Sun Yat-sen University
- Jian Jin
- Department of Rehabilitation, Zhujiang Hospital, Southern Medical University
- Jingyun Zhang
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- Binghuo Wu
- Key Laboratory of Stem Cells and Tissue Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Ministry of Education
- Yingying Zhang
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- Pei-hui Wu
- Department of Joint Surgery, the First Affiliated Hospital, Sun Yat-sen University
- Yangyang Lin
- Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University
- Wen Wu
- Department of Rehabilitation, Zhujiang Hospital, Southern Medical University
- Hu Zhao
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- Yan Zhang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University
- Wei-Jye Lin
- Brain Research Center, Sun Yat-sen Memorial Hospital and Zhongshan School of Medicine, Sun Yat-sen University
- Xiaojing Ye
- Faculty of Forensic Medicine, Guangdong Province Translational Forensic Medicine Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-022-32556-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.
