Toxins
(Jul 2016)
Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms
Jordan Debono,
Chip Cochran,
Sanjaya Kuruppu,
Amanda Nouwens,
Niwanthi W. Rajapakse,
Minami Kawasaki,
Kelly Wood,
James Dobson,
Kate Baumann,
Mahdokht Jouiaei,
Timothy N. W. Jackson,
Ivan Koludarov,
Dolyce Low,
Syed A. Ali,
A. Ian Smith,
Andrew Barnes,
Bryan G. Fry
Affiliations
Jordan Debono
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
Chip Cochran
Department of Earth and Biological Sciences, Loma Linda University, Loma Linda, CA 92350, USA
Sanjaya Kuruppu
Department of Biochemistry & Molecular Biology, Biomedical Discovery Institute, Monash University, Clayton, VIC 3800, Australia
Amanda Nouwens
School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia
Niwanthi W. Rajapakse
Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia
Minami Kawasaki
Aquatic Animal Health, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072 Australia
Kelly Wood
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
James Dobson
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
Kate Baumann
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
Mahdokht Jouiaei
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
Timothy N. W. Jackson
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
Ivan Koludarov
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
Dolyce Low
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
Syed A. Ali
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
A. Ian Smith
Department of Biochemistry & Molecular Biology, Biomedical Discovery Institute, Monash University, Clayton, VIC 3800, Australia
Andrew Barnes
Aquatic Animal Health, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072 Australia
Bryan G. Fry
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia
DOI
https://doi.org/10.3390/toxins8070210
Journal volume & issue
Vol. 8,
no. 7
Abstract
Read online
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledge gap, venom proteomics and toxin activity of species of Bothriechis, and Bothrops (including Bothriopsis) were investigated through established analytical methods. A combination of proteomics and bioactivity techniques was used to demonstrate a similar diversification of venom composition between large and small species within Bothriechis and Bothriopsis. Increasing our understanding of the evolution of complex venom cocktails may facilitate future biodiscoveries.
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