Piper longum catkin extract mediated synthesis of Ag, Cu, and Ni nanoparticles and their applications as biological and environmental remediation agents

Nargis Jamila; Naeem Khan; Amina Bibi; Adnan Haider; Sadiq Noor Khan; Amir Atlas; Umar Nishan; Aaliya Minhaz; Fatima Javed; Ahtaram Bibi

Arabian Journal of Chemistry (Aug 2020)

Piper longum catkin extract mediated synthesis of Ag, Cu, and Ni nanoparticles and their applications as biological and environmental remediation agents

Nargis Jamila,
Naeem Khan,
Amina Bibi,
Adnan Haider,
Sadiq Noor Khan,
Amir Atlas,
Umar Nishan,
Aaliya Minhaz,
Fatima Javed,
Ahtaram Bibi

Affiliations

Nargis Jamila: Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar 25000, Khyber Pakhtunkhwa, Pakistan; Corresponding author at: Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Naeem Khan: Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan; Corresponding author at: Department of Chemistry, Kohat University of Science and Technology, Kohat, Khyber Pakhtunkhwa, Pakistan.
Amina Bibi: Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar 25000, Khyber Pakhtunkhwa, Pakistan
Adnan Haider: Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Punjab, Pakistan
Sadiq Noor Khan: Department of Medical Lab Technology, University of Haripur, Haripur 22060, Khyber Pakhtunkhwa, Pakistan
Amir Atlas: Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan
Umar Nishan: Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan
Aaliya Minhaz: Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar 25000, Khyber Pakhtunkhwa, Pakistan
Fatima Javed: Department of Chemistry, Shaheed Benazir Bhutto Women University, Peshawar 25000, Khyber Pakhtunkhwa, Pakistan
Ahtaram Bibi: Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan

Journal volume & issue: Vol. 13, no. 8
pp. 6425 – 6436

Abstract

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Piper longum (long pepper) in dried form is used in several traditional medicines and as a spice. The present study highlights nutritional and toxic elements content, synthesis, and characterization of silver, copper oxide, and nickel nanoparticles using P. longum catkin extract. The study also determined anticancer, antioxidant, antimicrobial, and redox catalytic activities of the synthesized NPs. The P. longum extract mediated nanoparticles (PLNPs) synthesized at different pH and ratios were characterized by UV–Vis (ultra-violet-visible), FT-IR (Fourier-Transform infrared), and scanning electron and atomic force microscopic (SEM, AFM) techniques. Elemental content of P. longum catkin determined by inductively coupled plasma-optical emission spectroscopy (ICP-OES) and ICP-mass spectrometry (ICP-MS) indicated appreciable concentrations of nutritional elements, and well below permissible ranges of toxic elements. Well-defined and stable silver nanoparticles (PLAgNPs) were formed in 1:4 to 1:6 ratios, while copper oxide and nickel NPs (PLCuONPs and PLNiNPs) were found prominent in 1:6 ratio. In determining the effect of pH on synthesized PLNPs, sharp intense absorption peaks were obtained under slightly neutral to highly basic conditions (pH 6 to 13) for PLAgNPs, whereas for PLCuONPs and PLNiNPs, pH 7–8 was optimum. In biological activities, PLNPs exhibited significant anticancer efficacy against DU-145 (prostate cancer) cell line in the range from 92.7% (PLCuONPs) to 100% (PLAgNPs, PLNiNPs). Fuurthermore, the sythesized NPs exhibited significant antioxidant, antimicrobial, and redox catalytic properties. This study concluded the promising nutritional, biological and environmental remediation applications, and hence, further exploration of the synthesized NPs in biological and clinical applications is currently under investigation.

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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