Two mechanisms drive pronuclear migration in mouse zygotes

Kathleen Scheffler; Julia Uraji; Ida Jentoft; Tommaso Cavazza; Eike Mönnich; Binyam Mogessie; Melina Schuh

doi:10.1038/s41467-021-21020-x

Nature Communications (Feb 2021)

Two mechanisms drive pronuclear migration in mouse zygotes

Kathleen Scheffler,
Julia Uraji,
Ida Jentoft,
Tommaso Cavazza,
Eike Mönnich,
Binyam Mogessie,
Melina Schuh

Affiliations

Kathleen Scheffler: Department of Meiosis, Max Planck Institute for Biophysical Chemistry
Julia Uraji: Department of Meiosis, Max Planck Institute for Biophysical Chemistry
Ida Jentoft: Department of Meiosis, Max Planck Institute for Biophysical Chemistry
Tommaso Cavazza: Department of Meiosis, Max Planck Institute for Biophysical Chemistry
Eike Mönnich: Department of Meiosis, Max Planck Institute for Biophysical Chemistry
Binyam Mogessie: School of Biochemistry, University of Bristol
Melina Schuh: Department of Meiosis, Max Planck Institute for Biophysical Chemistry

DOI: https://doi.org/10.1038/s41467-021-21020-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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In a newly fertilized egg, maternal and paternal chromosomes are enclosed in two separate pronuclei but the mechanisms in mammals for pronuclear movement are unclear. Here, the authors report that both F-actin and microtubule polymerization act in concern to drive inward movement of pronuclei towards the cell centre.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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