Clinical and Translational Medicine (Aug 2022)
Screening of cell‐virus, cell‐cell, gene‐gene crosstalk among animal kingdom at single cell resolution
- Dongsheng Chen,
- Zhihua Ou,
- Jiacheng Zhu,
- Haoyu Wang,
- Peiwen Ding,
- Lihua Luo,
- Xiangning Ding,
- Chengcheng Sun,
- Tianming Lan,
- Sunil Kumar Sahu,
- Weiying Wu,
- Yuting Yuan,
- Wendi Wu,
- Jiaying Qiu,
- Yixin Zhu,
- Qizhen Yue,
- Yi Jia,
- Yanan Wei,
- Qiuyu Qin,
- Runchu Li,
- Wandong Zhao,
- Zhiyuan Lv,
- Mingyi Pu,
- Boqiong Lv,
- Shangchen Yang,
- Ashley Chang,
- Xiaofeng Wei,
- Fengzhen Chen,
- Tao Yang,
- Zhenyong Wei,
- Fan Yang,
- Peijing Zhang,
- Guoji Guo,
- Yuejiao Li,
- Yan Hua,
- Huan Liu
Affiliations
- Dongsheng Chen
- BGI‐Shenzhen Shenzhen China
- Zhihua Ou
- BGI‐Shenzhen Shenzhen China
- Jiacheng Zhu
- BGI‐Shenzhen Shenzhen China
- Haoyu Wang
- BGI‐Shenzhen Shenzhen China
- Peiwen Ding
- BGI‐Shenzhen Shenzhen China
- Lihua Luo
- BGI‐Shenzhen Shenzhen China
- Xiangning Ding
- BGI‐Shenzhen Shenzhen China
- Chengcheng Sun
- BGI‐Shenzhen Shenzhen China
- Tianming Lan
- BGI‐Shenzhen Shenzhen China
- Sunil Kumar Sahu
- BGI‐Shenzhen Shenzhen China
- Weiying Wu
- The MOE Frontier Science Center for Brain Research and Brain‐Machine Integration School of Brain Science and Brain Medicine Zhejiang University Hangzhou China
- Yuting Yuan
- Department of Physiology, School of Basic Medical Sciences Binzhou Medical University Yantai China
- Wendi Wu
- BGI‐Shenzhen Shenzhen China
- Jiaying Qiu
- BGI‐Shenzhen Shenzhen China
- Yixin Zhu
- BGI‐Shenzhen Shenzhen China
- Qizhen Yue
- BGI‐Shenzhen Shenzhen China
- Yi Jia
- BGI‐Shenzhen Shenzhen China
- Yanan Wei
- BGI‐Shenzhen Shenzhen China
- Qiuyu Qin
- BGI‐Shenzhen Shenzhen China
- Runchu Li
- BGI‐Shenzhen Shenzhen China
- Wandong Zhao
- BGI‐Shenzhen Shenzhen China
- Zhiyuan Lv
- BGI‐Shenzhen Shenzhen China
- Mingyi Pu
- BGI‐Shenzhen Shenzhen China
- Boqiong Lv
- BGI‐Shenzhen Shenzhen China
- Shangchen Yang
- College of Life Sciences Zhejiang University Hangzhou China
- Ashley Chang
- BGI‐Shenzhen Shenzhen China
- Xiaofeng Wei
- China National GeneBank Shenzhen China
- Fengzhen Chen
- China National GeneBank Shenzhen China
- Tao Yang
- China National GeneBank Shenzhen China
- Zhenyong Wei
- China National GeneBank Shenzhen China
- Fan Yang
- China National GeneBank Shenzhen China
- Peijing Zhang
- Center for Stem Cell and Regenerative Medicine Zhejiang University School of Medicine Hangzhou China
- Guoji Guo
- Center for Stem Cell and Regenerative Medicine Zhejiang University School of Medicine Hangzhou China
- Yuejiao Li
- BGI‐Shenzhen Shenzhen China
- Yan Hua
- Guangdong Provincial Key Laboratory of Silviculture Protection and Utilization Guangdong Academy of Forestry Guangzhou China
- Huan Liu
- BGI‐Shenzhen Shenzhen China
- DOI
- https://doi.org/10.1002/ctm2.886
- Journal volume & issue
-
Vol. 12,
no. 8
pp. n/a – n/a
Abstract
Abstract Background The exact animal origin of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) remains obscure and understanding its host range is vital for preventing interspecies transmission. Methods Herein, we applied single‐cell sequencing to multiple tissues of 20 species (30 data sets) and integrated them with public resources (45 data sets covering 26 species) to expand the virus receptor distribution investigation. While the binding affinity between virus and receptor is essential for viral infectivity, understanding the receptor distribution could predict the permissive organs and tissues when infection occurs. Results Based on the transcriptomic data, the expression profiles of receptor or associated entry factors for viruses capable of causing respiratory, blood, and brain diseases were described in detail. Conserved cellular connectomes and regulomes were also identified, revealing fundamental cell‐cell and gene‐gene cross‐talks from reptiles to humans. Conclusions Overall, our study provides a resource of the single‐cell atlas of the animal kingdom which could help to identify the potential host range and tissue tropism of viruses and reveal the host‐virus co‐evolution.
Keywords
