Artery Research (Feb 2020)

P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients

  • Angela Cozma,
  • Adriana Fodor,
  • Vasile Negrean,
  • Dorel Sampelean,
  • Ionut Minciuna,
  • Monica Oltean,
  • Ionela Popovici,
  • Sorina Coste,
  • Alexandra Dadarlat,
  • Dana Pop,
  • Olga Hilda Orasan,
  • Adela-Viviana Sitar-Taut

DOI
https://doi.org/10.2991/artres.k-191224.169
Journal volume & issue
Vol. 25, no. S1
pp. S186 – S186

Abstract

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Abstract Background Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance. Purpose To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients. Methods 88 patients (66 women), mean age 61.96 ± 10.15. Cardiovascular risk factors (body weight, waist circumference, lipid fractions, smoking, diabetes, hypertension) and chemerin were assessed. Insulin resistance scores were calculated: Homeostatic model assessment (HOMA) = insulin (μU/mL)* glicemia (mg/dl)/405 and Quantitative insulin sensitivity check index (QUICKI = 1/[lg10 (insulin (μU/mL)) + lg10 (glicemia)]. Patients were categorized in obese only (20.5%), diabetics only (12.5%), obese and diabetics (14.8%) and non-diabetics-non obese (52.3%). Results 35.3% patients were obese, 27.3% diabetics, 79.5% hypertensive, 17% current smokers, 67% dyslipidaemic. The values of chemerin registered in the four groups were as follows: in diabetic + obese patients 7.98 ± 7.22 pg/ml (median 5.2), diabetics only 7.27 ± 5.24 pg/ml (5.6), obese only 8.42 ± 7.56 pg/ml (median 5.8), non-obese-non-diabetics 9.15 ± 7.64 pg/ml (median 7.15). Globally chemerin did not correlate with waist circumference, HDL-cholesterol, LDL-cholesterol, glicemia, insulin, HOMA index or QUICKI index. Going further with analysis, no significant correlations were found between chemerin and HOMA index and QUICKI index in diabetic + obese patients, obese only patients, diabetics only. But, in non-obese-non-diabetics significant correlations were found — between chemerin and glicemia (r = 0.3), HOMA index (r = 0.3, p = 0.03), QUICKI index (r = -0.310, p = 0.037), but not with waist circumference (r = 0.224, p = NS), HDL (r = 0.08, p = NS) or LDL (r = -0.06, p = NS). Conclusion Although many things need to be elucidated regarding the chemerin mechanism, it seems very probable to be involved in early insulin resistance.