A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity

Xia Li; Xiupeng Wang; Atsuo Ito; Noriko M. Tsuji

doi:10.1038/s41467-020-17637-z

Nature Communications (Jul 2020)

A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity

Xia Li,
Xiupeng Wang,
Atsuo Ito,
Noriko M. Tsuji

Affiliations

Xia Li: Department of Life Science and Biotechnology, Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
Xiupeng Wang: Department of Life Science and Biotechnology, Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
Atsuo Ito: Department of Life Science and Biotechnology, Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
Noriko M. Tsuji: Department of Life Science and Biotechnology, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

DOI: https://doi.org/10.1038/s41467-020-17637-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Nanoparticle-based strategies have been proposed to enhance the benefit of cancer immunotherapy. Here the authors show that a cancer vaccine based on metal organic frameworks-gated mesoporous silica nanoparticles for antigen and immune potentiators delivery boosts the therapeutic efficacy of low-dose anti-PD1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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